Neuronal Input Pathways to the Brains Biological Clock and their Functional Significance
Jens Hannibal, J. Fahrenkrug
Rhythmic changes in physiology and behaviour within a 24 h period occur in living organisms on earth to meet the challenges associated with the daily changes in the external environment. The circadian pacemaker responsible for the temporal internal organisation and the generation of endogenous rhythms of approximately 24 h is located in the hypothalamic suprachiasmatic nucleus (SCN) in mammals. The endogenous period generated by the pacemaker is close to, but generally not equal to 24 h and the biological clock therefore needs to be daily adjusted (entrained) by external cues. The daily alteration of light and darkness due to the rotation of our planet on its own axis in relation to the sun is the most prominent "zeitgeber" which adjusts the phase of the circadian rhythms to the astronomical day length, a process known as photoentrainment. In mammals, light is perceived only through photoreceptors located in the retina. Light information is mediated to the SCN via the retinohypothalamic tract (RHT) by activation of the classical photoreceptor system of rods and cones and a more recently identified system of intrinsic photosensitive retinal ganglion cells (ipRGCs) using melanopsin as a photopigment.
Categories:
Year:
2005
Edition:
1
Publisher:
Springer
Language:
english
Pages:
83
ISBN 10:
3540277889
ISBN 13:
9783540277880
Series:
Advances in Anatomy, Embryology and Cell Biology
File:
PDF, 1.20 MB
IPFS:
,
english, 2005
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